Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?

    loading  Checking for direct PDF access through Ovid


Cardiac fibroblasts have been long recognized as active participants in heart disease; however, their exact physiological and pathological roles remain elusive, mainly due to the lack of specific markers. In this issue of theJCI, Moore-Morris and colleagues used a fibroblast-specific collagen1a1-GFPreporter to demonstrate that fibroblast accumulation after aortic banding in murine hearts arises almost exclusively from proliferation of resident fibroblasts originating from both the epicardium and a previously unrecognized source, the endocardium. Further characterization of fibroblast origin and function in different types and stages of heart disease could lead to development of improved fibroblast-targeted cardiac therapies.

Related Topics

    loading  Loading Related Articles