Transcriptional regulation of autophagy in RAS-driven cancers

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RAS-driven cancers exhibit variable dependency on autophagy for survival; however, it is not fully understood how. In this issue of the JCI, Cheong and colleagues demonstrate that RAS-dependent elevation of casein kinase 1? (CK1?) negatively regulates autophagy at the level of autophagy gene transcription. Moreover, combined inhibition of both CK1? and autophagy reduced proliferation of RAS-driven tumors. The results of this study provide insight into the connection between mutant RAS and autophagy, and suggest targeting CK1? as a potential therapeutic strategy to modulate autophagy in RAS-driven cancers.

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