The new estimated glomerular filtration (eGFR) equation, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, was recently introduced. We compared the prevalence of CKD examined by the CKD-EPI equation with that by the Modification of Diet in Renal Disease (MDRD) equation.Methods:
We analyzed the data from a total of 14,605 Korean adults (age ≥20 years), who were enrolled in the Korean National Health and Nutrition Examination Survey in 2007, 2009, and 2010. CKD stages 1 and 2 were defined as eGFR ≥60 mL/min/1.73 m2 with proteinuria measured by dipstick. CKD stages 3–5 were defined as eGFR <60 mL/min/1.73 m2.Results:
The eGFRs calculated by the CKD-EPI equation were higher than those calculated by the MDRD equation (P < 0.001), especially in women and young people. The prevalence of CKD stages 3–5 calculated by the MDRD equation was 6.8%, 3.0%, and 3.0% in 2007, 2009, and 2010, respectively. The prevalence of CKD stages 3–5 calculated by CKD-EPI equation was 7.7%, 2.7%, and 2.6% in 2007, 2009, and 2010, respectively. When defining the CKD using the CKD-EPI equation, 55 (32.7%) of 350 cases were reclassified into more advanced stages and 295 cases (67.3%) were reclassified into less-advanced stages.Conclusion:
The CKD-EPI equation caused an overall low prevalence of CKD compared to the MDRD. Therefore, CKD-EPI equation might be helpful to prevent an overestimation of CKD.