Continuous assessment of central venous oxygen saturation (ScevoxO2) with the CeVOX device (Pulsion Medical Systems, Munich, Germany) was evaluated against central venous oxygen saturation (ScvO2) determined by co-oximetry.Methods
In 20 cardiac surgical patients, a CeVOX fiberoptic probe was introduced into a standard central venous catheter placed in the right internal jugular vein and advanced 2-3 cm beyond the catheter tip. After in vivo calibration of the probe, ScevoxO2, ScvO2, mixed venous oxygen saturation (SmvO2) haemoglobin (Hb), body temperature, heart rate, central venous and mean arterial pressure, and cardiac index were assessed simultaneously at 30 min intervals during surgery and at 60 min intervals during recovery in the intensive care unit. Agreement between ScevoxO2, and ScvO2 was determined by Bland-Altman analysis. Simple regression analysis was used to assess the correlation of ScevoxO2, and ScvO2 to Hb, body temperature and haemodynamic parameters.Results
Values of ScevoxO2 and ScvO2 (84 data pairs during surgery and 106 in the intensive care unit) ranged between 45-89% and 43-90%, respectively. Mean bias and limits of agreement of ScevoxO2 and ScvO2 were -0.9 (-7.9/+6.1)% during surgery and -1.2 (-10.5/+8.1)% in the intensive care unit. In 37.9% of all measured data pairs, the difference between ScevoxO2 and ScvO2 was beyond clinically acceptable limits (≥1 s.d.). Mean bias was significantly influenced by cardiac index. Sensitivity and specificity of ScevoxO2 to detect substantial (≥1 s.d.) changes in ScvO2 were 89 and 82%, respectively.Conclusions
In adult patients during and after cardiac surgery, the current version of the CeVOX device might not be the tool to replace ScvO2 determined by co-oxymetry, although sensitivity and specificity of ScevoxO2 to predict substantial changes in ScvO2 were acceptable.