Participants (N = 222) completed measures of negative mood regulation (NMR) expectancies, negative life events, coping responses, dysphoria, and somatic symptoms. After 6 to 8 weeks, they completed the same questionnaires except that daily hassles in the previous month were assessed instead of negative life events. In cross-sectional analyses and with stable variance in coping and symptoms controlled, NMR expectancies were positively related to active coping and negatively related to avoidant coping and symptoms. Changes in NMR expectancies and dysphoria were correlated. Time 1 dysphoria was positively related to daily hassles at Time 2, which in turn was associated with changes in coping and dysphoria from Time 1 to Time 2. Implications for counseling and stress-management interventions are discussed.