High molecular weight caldesmon positive stromal cells in the capsule of hepatocellular carcinomas

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Abstract

Aims:

To investigate the smooth muscle nature of the stromal cells in the capsule of hepatocellular carcinomas.

Methods:

Immunohistochemical analysis using monoclonal antibody to high molecular weight caldesmon (HCD), a highly specific marker for smooth muscle cells, was performed in 33 encapsulated hepatocellular carcinomas and adjacent hepatic tissues.

Results:

HCD positive stromal cells were detected in the capsule of 21 of the 33 hepatocellular carcinomas examined.

Conclusions:

The capsule of hepatocellular carcinomas contains smooth muscle cells.

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