KIR genotype distribution among symptomatic patients with and withoutHelicobacter pyloriinfection: is there any role for theBhaplotype?

    loading  Checking for direct PDF access through Ovid


Contact of peripheral blood lymphocytes with Helicobacter pylori was proved to induce non- major histocompatibility complex-restricted cytotoxicity and natural killer cells are thought to play an important role in the immunity against H. pylori.


In this research, we investigated any possible association between killer immunoglobulin-like receptors (KIR) genotypes and H. pylori infection.


KIR genotype was analysed in 101 Lebanese symptomatic patients (51 H. pylori positive and 50 H. pylori-negative) using the KIR Genotyping SSP kit.


Among the H. pylori-positive patients, the AA, AB and BB genotypical frequencies were, respectively, 43.14%, 41.18% and 15.68% with an A:B ratio of 1.76:1. The AA, AB and BB genotypes frequencies for H. pylori-negative individuals were 18%, 62% and 20%, respectively, with an A:B ratio of 0.96:1. No significant difference between patients and controls was detected.


We noticed a reduced distribution of A haplotype among the ‘H. pylori-negative’ patients as compared with the “H. pylori-positive” group. This is the first study in the international literature that targets the correlation between KIR genotypes and H. pylori.

Related Topics

    loading  Loading Related Articles