Paradoxical Actions of Quinidine in Hyperpermeable Heart Cells

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Abstract

Summary:

The effect of quinidine on the inotropic state was examined using small fragments of hyperpermeable ventricular muscle in vitro. In concentrations of 10-13 and 10-4 M, quinidine had no effect on the force of spontaneously contracting fibers. At a concentration of 10-3 M, contractile force increased by at least twofold. We conclude that the negative inotropic action of quinidine is not by a direct action on intracellular organelles of the heart.

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