An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect®

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To evaluate the effects of a capsule formulation of an antioxidant polyphenolic extract of grapes on serum total antioxidant activity and vitamin C and E levels.


A single-blinded randomised, placebo-controlled cross-over study was undertaken in 20 young volunteers. Subjects were given two capsules containing 300 mg of grape procyanidin extracts (Leucoselect™-phytosome®) or placebo daily for 5 days. Blood samples were taken at the start of the study and end of the study and assayed for antioxidant activity and vitamins C and E levels. After a washout period of at least 2 weeks, the study was repeated with the second treatment.


The extract had no effect on serum vitamins C and E levels but increased serum total antioxidant activity (TAC). On day 5, TAC increased from 408·1 ± 22·9 to 453·3 ± 453·3 µmol/l trolox equivalents 1 hour postdose.


The capsules increased serum antioxidant activity but the longer-term clinical implications need to be assessed in further randomised clinical trials.

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