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Poor insight is prevalent among patients with schizophrenia and improved insight is one of the major goals of treatment. The purpose of the present study was to examine the relationship between insight and subjective well-being during acute treatment of schizophrenia with atypical antipsychotics in a naturalistic clinical setting.Forty inpatients with schizophrenia were examined before and 8 weeks after the initiation of new treatment with atypical antipsychotics.There were significant correlations between changes in insight and those in psychopathology and global functioning. The change in insight score was significantly correlated with that in subjective well-being score, indicating that the improvement in insight was positively related to improved subjective well-being. This correlation remained significant even after controlling for the influence of psychopathology. The insight score at baseline was also significantly correlated with the subsequent change in subjective well-being score.The improvement of insight was positively correlated not only with that of psychopathology and global functioning, but also with that of subjective well-being, suggesting the potential value of interventions that improve patients' awareness of the nature of their illness and the need for pharmacological treatment.