AbstractWhat is known and objective:
Febuxostat is recommended as an alternative drug for gouty patients with a history of allopurinol hypersensitivity or carrying theHLA-B*5801allele.Case summary:
An 81-year-old man with the medical history of gout presented to our clinic with generalized rashes for 2 days. After taking febuxostat for 2 days, he developed generalized skin rash with high fever. Laboratory tests showed elevated liver enzymes and acute kidney injury.What is Known and Objective:
This is the first identified case of febuxostat-associated DRESS. Febuxostat should be withdrawn immediately when DRESS is observed to avoid further serious complications.
Time course of liver function tests.