Febuxostat-associated drug reaction with eosinophilia and systemic symptoms (DRESS)

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What is known and objective:

Febuxostat is recommended as an alternative drug for gouty patients with a history of allopurinol hypersensitivity or carrying theHLA-B*5801allele.

Case summary:

An 81-year-old man with the medical history of gout presented to our clinic with generalized rashes for 2 days. After taking febuxostat for 2 days, he developed generalized skin rash with high fever. Laboratory tests showed elevated liver enzymes and acute kidney injury.

What is Known and Objective:

This is the first identified case of febuxostat-associated DRESS. Febuxostat should be withdrawn immediately when DRESS is observed to avoid further serious complications.

Time course of liver function tests.

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