Probable interaction between acenocoumarol and levofloxacin: a case series

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Abstract

What is known and objective:

To report five cases with a probable interaction between acenocoumarol and levofloxacin.

Case description:

In five patients on long-term acenocoumarol treatment who had had stable international normalized ratios for at least 6 months, sudden erratic changes in the values of these ratios were observed after 1.5–8 days of concomitant levofloxacin treatment with no other apparent cause.

What is new and conclusions:

Closer monitoring should be considered in patients with concomitant use of acenocoumarol and levofloxacin, especially elderly patients and those with renal dysfunction who seemed to suffer the interaction more severely.

This case report describes the probable drug-drug interaction between levofloxacin and acenocoumarol. Closer monitoring should be considered in patients with concomitant use of these drugs, especially elderly patients and those with renal dysfunction.

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