|| Checking for direct PDF access through Ovid
Sepsis can lead to poor outcomes when treatment is delayed or inadequate. The purpose of this study was to evaluate outcomes after initiation of a hospital-wide sepsis alert program.Retrospective review of patients ≥ 18 years treated for sepsis.There were 3917 sepsis admissions: 1929 admissions before, and 1988 in the after phase. Mean age (57.3 vs. 57.1, p = 0.94) and Charlson Comorbidity Scores (2.52 vs. 2.47, p = 0.35) were similar between groups. Multivariable analyses identified significant reductions in the after phase for odds of death (OR 0.62, 95% CI 0.39–0.99, p = 0.046), mean intensive care unit LOS (2.12 days before, 95%CI 1.97, 2.34; 1.95 days after, 95%CI 1.75, 2.06; p < 0.001), mean overall hospital LOS (11.7 days before, 95% CI 10.9, 12.7 days; 9.9 days after, 95% CI 9.3, 10.6 days, p < 0.001), odds of mechanical ventilation use (OR 0.62, 95% CI 0.39, 0.99, p = 0.007), and total charges with a savings of $7159 per sepsis admission (p = 0.036). There was no reduction in vasopressor use (OR 0.89, 95% CI 0.75, 0.1.06, p = 0.18).A hospital-wide program utilizing electronic recognition and RRT intervention resulted in improved outcomes in patients with sepsis.EHR-based, sepsis-recognition tool provided hourly, hospital-wide sepsis screening.Adjusted MEWS-SRS score was tailored to screen for sepsis at our institution.Nurse-led Rapid Response Team was instrumental in sepsis care delivery on the wards.Hospital-wide sepsis alert order set was based on a simplified 3 h bundle.Associated reductions in mortality, length of stay, and mechanical ventilation use.