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Monocyte Chemotactic Protein 1 (MCP1) and latest sepsis-3 criteria are poorly represented within studies evaluating biomarkers in sepsis. Therefore, this study evaluates the prognostic value of MCP-1 compared to interleukin-6 (IL-6) in patients with sepsis and septic shock according to sepsis-3 criteria.136 patients with sepsis or septic shock were included within 24 h of intensive care unit (ICU) admission. MCP-1, IL-6, procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC) were measured on days 1, 3 and 8. All-cause mortality was followed up at 30 days and 6 months.Both MCP-1 and IL-6 levels revealed valuable prognostic discrimination of 30-day and 6-months all-cause mortality on day 1 and 3 (MCP-1: range of AUCs 0.62–0.65, p < 0.039; IL-6: range of AUCs 0.65–0.70, p < 0.021) compared to PCT, CRP, SOFA and APACHE II score. MCP-1 levels within the 4th quartile revealed the highest mortality at 30 days and 6 months compared to patients with lower levels (range of hazard ratio (HR) = 2.1–3.3, p < 0.041). The prognostic value of MCP-1 sustained in multivariate regression models and was comparable to that of IL-6.Both MCP-1 and IL-6 revealed prognostic value for short- and mid-term all-cause mortality in patients with sepsis and septic shock according to latest sepsis-3 definitions.MCP-1 and IL-6 were evaluated according to sepsis-3 criteria.MCP-1 and IL-6 revealed valuable prognostic value for all-cause mortality at 30 days and 6 months.MCP-1 and Il-6 reveal strongest prognostic value in patients suffering from septic shock.