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The Sepsis-3 definition provides a change of two or more scores from zero or a known baseline of the Sequential Organ Failure Assessment (SOFA) as criteria of sepsis. The aim of this study was to compare the SOFA score and the quick SOFA (qSOFA) to Systemic Inflammatory Response Syndrome (SIRS) criteria in predictive ability of mortality and organ failure.A-10 year retrospective cohort study was conducted in a teaching hospital in Thailand.A total of 2350 of mixed sepsis patients by Sepsis-2 definition were included. The all-cause hospital mortality rate was 44.5%. Of the total sample, 95.6% (n = 2247) of patients met criteria for sepsis under the Sepsis-3 definition. The SOFA score presented the best discrimination with an area under the receiver operating characteristic curve (AUC) of 0.839. The AUC of SOFA score for hospital mortality was significantly higher than qSOFA (AUC 0.814, P = 0.003) and SIRS (AUC 0.587, P < 0.0001). Also, the SOFA score had superior performance than other scores for predicting intensive care unit (ICU) mortality and organ failure.The SOFA is a superior prognostic tool for predicting mortality and organ failure than qSOFA and SIRS criteria among sepsis patients admitted to the ICU.SOFA score provide a better predictive ability to predict mortality than qSOFA and SIRS criteria among ICU sepsis patients.qSOFA score had a better prognostic accuracy for mortality and organ failure than SIRS criteria.SIRS criteria more than 2 were common in ICU sepsis patients but offered poor outcome prediction.This study results support the application of SOFA for screening diagnosis of ICU sepsis patients as Sepsis-3 recommendation.