Pemetrexed-Induced Eyelid Edema in Lung Cancer

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Pemetrexed is a novel, multitargeted antifolate approved for the treatment of malignant pleural mesothelioma and non–small cell lung cancer. Although pemetrexed is a safe drug, some adverse effects such as myelosupression and cutaneous reactions are observed. Pemetrexed-induced eyelid edema is a rare side effect of pemetrexed treatment, and until this moment few cases were reported in the medical literature. We reported a new case of pemetrexed-induced eyelid edema in a patient with adenocarcinoma of the lung with brain metastases.

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