The primary objective of this study was to verify the effects of bacteriocin in treatment of postoperative infection of mandibular fracture in vivo.Methods:
Eighty-two mice were inoculated intravenously with staphylococcal suspensions. Bacterial cultures were obtained from implants. Blood samples were collected at 1, 2, 4, 6, and 8 hours after the injection of bacteriocins.Results:
Bacteriocins have significant inhibitory effects on Staphylococcus aureus (P < 0.05) and there are significant differences interleukin (IL)-8 and IL-10 in serum (P < 0.05).Conclusions:
Bacteriocin isolated from L plantarum may be one of promising ways to control postoperative infection of mandibular fracture in vivo.