Zinc-Replacement Therapy may not Reduce Oral Pain in Patients with Zinc-Deficient Burning Mouth Syndrome (BMS)

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Article Title and Bibliographic Information

Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects.

Article Title and Bibliographic Information

Cho GS, Han MW, Lee B, Roh J, Choi S, Cho K, et al.

Article Title and Bibliographic Information

J Oral Pathol Med 2010;39(9):722–7.


Vinodh Bhoopathi, BDS, MPH, DScD, Ana Karina Mascarenhas, BDS, MPH, DrPH


In patients with BMS and low serum zinc levels, does zinc-replacement therapy reduce pain? Authors using an animal model also attempted to demonstrate a causal relationship between BMS and zinc deficiency

Source of Funding

Information not available

Type of Study/Design

Randomized controlled trial

Level of Evidence

Level 2: Limited-quality, patient-oriented evidence

Strength of Recommendation Grade

Not applicable

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