Low-Dose Doxycycline Plus Additional Therapies may Lower Systemic Inflammation in Postmenopausal Women with Periodontitis

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Article Title and Bibliographic Information

The effect of subantimicrobial-dose–doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial.

Article Title and Bibliographic Information

Payne JB, Golub LM, Stoner JA, Lee H-M, Reinhardt RA, Sorsa T, Slepian MJ.

Article Title and Bibliographic Information

J Am Dent Assoc 2011;142;262–73.


Walter A. Bretz, DDS, PhD


To determine whether long-term subantimicrobial-dose–doxycycline (SDD) periodontal therapy could reduce serum biomarkers of systemic inflammation and improve lipid profiles in postmenopausal women who have systemic osteopenia and chronic periodontitis

Source of Funding

NIH/NIDCR grant R01DE012872.

Type of Study/Design

Randomized controlled trial

Level of Evidence

Level 2: Limited-quality, patient-oriented evidence

Strength of Recommendation Grade

Not applicable

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