Preoperative Oral Use of Ibuprofen or Dexamethasone May Improve the Anesthetic Efficacy of an Inferior Alveolar Nerve Block in Patients Diagnosed With Irreversible Pulpitis

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Article Title and Bibliographic Information

Effect of premedication with ibuprofen and dexamethasone on success rate of inferior alveolar nerve block for teeth with asymptomatic irreversible pulpitis: a randomized clinical trial.

Article Title and Bibliographic Information

Shahi S, Moktari H, Rahimi S, Yavari HR, Narimani S, Abdolrahmi M, Nezafati S.

Article Title and Bibliographic Information

J Endod 2013;39(2):160-2.


John M. Nusstein, DDS, MS


To determine whether preoperative oral administration of ibuprofen (400 mg), dexamethasone (0.5 mg), or placebo (lactose) would improve the anesthetic success rate of an inferior alveolar nerve block in patients with molars diagnosed with asymptomatic irreversible pulpitis

Source of Funding

University: Dental and Periodontal Research Center of Tabriz, Tabriz University of Medical Sciences, Tabriz, Iran

Type of Study/Design

Randomized controlled trial

Level of Evidence

Level 2: Limited-quality, patient-oriented evidence

Strength of Recommendation Grade

Not applicable

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