Use of Bis-Alkaloid Derivatives of Dicarboxylic Acids on the Basis of Lupinine, Anabasine and Cytisine as Reversible Inhibitors of Cholinesterases of Different Origin

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Abstract

Comparative study was carried out on action of a group of bis-alkaloid derivatives (on the basis of lupinine, anabasine, and cytosine, and their iodomethylates) of dicarboxylic acids (succinic, glutaric, azelaic, sebacic) on activity of cholinesterase of optical ganglia of the Commander squid Berryteuthis magister from different zones of habitation in the northwest part of the Pacific Ocean as well as human erythrocyte acetylcholinesterase and horse serum butyrylcholinesterase. These compounds turned out to be potent reversible inhibitors with specificity of action with respect both of sensitivity of the studied enzymes to them and of the type of their inhibitory action. The studied inhibitors can be used as tools in biochemical taxonomy to determine populational structure of such a marketing species as the Commander squid Berryteuthis magister.

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