Investigation of Cholinesterases of Different Origin by the Method of Inhibitor Analysis (Variation of Structure of Phosphoryl Part of Alkoxyalkylthiophosphonates)

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Abstract

Analytical review of literature data is carried out on inhibitor analysis of structure of cholinesterases in various animals (vertebrates, insects, and molluscs) by studying their interaction with 68 alkoxyalkylthiophosphonates of 10 homologous series with regularly changed structure of phosphoryl part. The presented data are discussed in the comparative-enzymological aspect of current concepts of structure of active center of cholinesterases.

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