Role of Acetylcholine in Ca2+-Dependent Regulation of Functional Activity of the Frog Rana temporaria Myocardium

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Abstract

To study role of acetylcholine (ACh) in Ca2+-dependent regulation of rhythm and strength of cardiac contractions in the frog Rana temporaria, we studied in parallel experiments the ACh chrono- and inotropic effects on the background of action of blockers of the potential-controlled Ca2+-channels, ryanodine and muscarine receptors. The obtained results indicate participation of acetylcholine in the Ca2+-dependent regulation of the rhythm and strength of the frog cardiac contractions.

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