This study explored the effects of ABRACADABRA, a free computer-assisted literacy program, on the reading accuracy and comprehension skills of children diagnosed with autism spectrum disorder (ASD). ABRACADABRA is a balanced literacy instruction program, targeting both code and meaning-based reading abilities. Twenty children with ASD, aged 5–11 years, were assigned by matched pairs to the instruction group or wait-list control group. Literacy instruction was delivered on a 1:1 basis in participants’ homes over a 13-week period (26 sessions per participant). Pre and post instruction assessment using standardized measures revealed statistically significant gains in reading accuracy and comprehension for the instruction group relative to the wait-list control group, with large effect sizes. These findings indicate that children with ASD may benefit from ABRACADABRA literacy instruction.