Parathyroid Hormone, Ionized Calcium, and 25-Hydroxyvitamin D Concentrations in the Domestic Ferret (Mustela putorius furo)

    loading  Checking for direct PDF access through Ovid


The objective of this study was to measure parathyroid hormone (PTH), ionized calcium, and 25-hydroxyvitamin D concentrations in healthy intact adult ferrets. Serum was collected from 16 clinically healthy adult ferrets (8 males and 8 females). Concentrations of PTH and 25-hydroxyvitamin D were measured via commercially available radioimmunoassays validated for humans, dogs, and cats (PTH) plus horses (25-hydroxyvitamin D). Concentrations of ionized calcium (at pH 7.4) were measured using an ion-specific electrode. Median (minimum, maximum) concentrations were as follows: PTH 8.7 (2.2, 24.4) pmol/L, ionized calcium 1.15 (1.09, 1.25) mmol/L, and 25-hydroxyvitamin D 94 (61, 138) nmol/L). Female ferrets had significantly higher concentrations of PTH than male ferrets (female median: 17.1 pmol/L; male median: 6.9 pmol/L). Associations among PTH, ionized calcium, 25-hydroxyvitamin D, calcium, phosphorus, magnesium, and weight were evaluated. There was a weak negative correlation between PTH concentration and total calcium concentration in female ferrets. As none of these assays have been validated for use in ferrets, results may provide a baseline for clinicians evaluating ferrets for disorders of calcium homeostasis, parathyroid glands, and paraneoplastic syndromes.

    loading  Loading Related Articles