Microstructured Arrays with Pre-synthesized Capture Probes for DNA Detection Based on Metal Nanoparticles and Silver Enhancement

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DNA microarrays exhibiting highly defined squared spot geometry and increased homogeneity in capture DNA distribution were prepared by a combination of microfabrication and DNA spotting. The microfabricated substrates were tested using metal nanoparticles as markers. The optical absorption signal is improved by a silver enhancement step. Experiments demonstrated the specificity and the concentration-dependency of the signal.

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