Advise patients with uncontrolled hypertension to take at least one of their blood pressure (BP) medications at bedtime instead of in the morning. Nighttime dosing leads to better control and lowers the risk of major cardiovascular events.1,2STRENGTH OF RECOMMENDATION
B: Based on a well-done randomized clinical trial (RCT) and a subgroup analysis.STRENGTH OF RECOMMENDATION
Hermida RC, Ayala DE, Mojón A, et al. Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study. Chronobiol Int. 2010;27:1629-1651.STRENGTH OF RECOMMENDATION
Hermida RC, Ayala DE, Mojón A, et al. Influence of time of day of blood pressure-lowering treatment on cardiovascular risk in hypertensive patients with type 2 diabetes. Diabetes Care. 2011;34:1270-1276.