Inform patients who are interested in taking varenicline (Chantix) that there is a small cardiovascular (CV) risk associated with it, as well as neuropsychiatric risks—and consider recommending that smokers with a history of cardiovascular disease (CVD) use nicotine replacement therapy (NRT) or bupropion instead.1PRACTICE CHANGER
STRENGTH OF RECOMMENDATIONPRACTICE CHANGER
A: Based on a meta-analysis.PRACTICE CHANGER
Singh S, Loke YK, Spangler JG, et al. Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and metaanalysis. CMAJ. 2011;183:1359-1366.