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For many smokers, the benefits of quitting will outweigh the risks associated with varenicline.Inform patients who are interested in taking varenicline (Chantix) that there is a small cardiovascular (CV) risk associated with it, as well as neuropsychiatric risks—and consider recommending that smokers with a history of cardiovascular disease (CVD) use nicotine replacement therapy (NRT) or bupropion instead.1STRENGTH OF RECOMMENDATIONA: Based on a meta-analysis.Singh S, Loke YK, Spangler JG, et al. Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and metaanalysis. CMAJ. 2011;183:1359-1366.