Q / Is high-dose oral B12 a safe and effective alternative to a B12 injection?

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Abstract

EVIDENCE-BASED ANSWER

A/YES. Both high-dose oral B12 and injected B12 raised low vitamin B12 levels and improved hematologic parameters and neurologic symptoms in short-term studies (3-4 months) predominantly involving patients with conditions associated with intestinal malabsorption (strength of recommendation: A, randomized controlled trials [RCTs]).

EVIDENCE-BASED ANSWER

Both forms are well tolerated. Oral B12 is less expensive.

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