Q/How best to treat agitation in patients with irreversible dementia?

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Abstract

EVIDENCE-BASED ANSWER

A/ATYPICAL ANTIPSYCHOTICS modestly reduce agitation compared with placebo but have significant adverse effects (strength of recommendation [SOR]: A, systematic reviews of randomized controlled trials [RCTs]).

EVIDENCE-BASED ANSWER

Haloperidol doesn't reduce symptoms and has serious adverse effects (SOR: A, systematic reviews of RCTs).

EVIDENCE-BASED ANSWER

Selective serotonin reuptake inhibitors (SSRIs) and melatonin—although well tolerated—don't reduce agitation (SOR: B, extrapolated data from systematic reviews of RCTs).

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