1Department of Medicine Johns Hopkins Medical Institutions BaltimoreMaryland USA 2Department of Medicine, Division of Gastroenterology Johns Hopkins Medical Institutions BaltimoreMaryland USA 3Department of Medicine, Division of Gastroenterology University of Pennsylvania Perelman School of Medicine PhiladelphiaPennsylvania USA 4 Helios HSK Clinic Wiesbaden Germany 5Department of Pathology Johns Hopkins Medical Institutions BaltimoreMaryland USA 6Department of Medicine, Division of Gastroenterology Washington University School of Medicine St. LouisMissouri USA