We report a case of an 84-year-old man who had an Ex-PRESS R-50 glaucoma shunt placed under a scleral flap in his right eye for primary open angle glaucoma and uncontrolled intraocular pressure. Twenty-one days after placing the implant, the patient returned with a dislocated shunt resting in the inferior angle of the anterior chamber. Corrected vision was 20/30 with an intraocular pressure of 13 mm Hg. There was no anterior chamber inflammation and no evidence of corneal decompensation. To our knowledge, this is the first report of an Ex-PRESS shunt dislocation into the anterior chamber. Ophthalmologists implanting this device should be aware of this possible complication of Ex-PRESS shunt insertion.