Relationship Between OCT Angiography Temporal Peripapillary Vessel-Density and Octopus Perimeter Paracentral Cluster Mean Defect

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Purpose of the Study:

The purpose of the study was to investigate the relationship between optical coherence tomography angiography angioflow vessel-density (PAFD) measured in the retinal nerve fiber layer in the temporal peripapillary sector and the average of the spatially corresponding superior and inferior paracentral cluster mean defect values (mean paracentral MD) measured with Octopus perimetry.

Materials and Methods:

Spaerman’s correlation between temporal peripapillary PAFD acquired with the Angiovue OCT and mean paracentral MD measured with the Normal and tendency-oriented perimetry strategy of Octopus G2 perimetry, respectively, was determined on 1 eye of 13 healthy participants, 22 medically controlled ocular hypertensive, and 27 stable early to moderate glaucoma patients. Octopus perimetry was made within 3 months from optical coherence tomography angiography imaging.


Strong negative relationship was found irrespective to Octopus test strategy between temporal sector peripapillary PAFD and mean paracentral MD for the total population (r-values: −0.5525 and −0.4496, respectively, P≤0.002), the glaucoma group (r-values: −0.4901 and −0.4936, respectively, P<0.01) and the ocular hypertensive group (r-values: −0.4445 and −0.4496, P≤0.0382). For the healthy eyes, and for all groups when correction for the diffuse defect component of global MD was made using the perimeter’s software, no significant relationship was found.


Strong negative relationship exists between the temporal peripapillary sector PAFD measured with Angiovue OCT angiography in the retinal nerve fiber layer and mean paracentral cluster MD determined with uncorrected Normal and tendency-oriented perimetry strategies of Octopus perimetry. This relationship may be usefully applied in research when eyes with paracentral scotomas are investigated.

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