Preoperative Brimonidine Tartrate 0.2% does not Prevent an Intraocular Pressure Rise During Prostatectomy in Steep Trendelenburg Position

    loading  Checking for direct PDF access through Ovid

Abstract

Purpose:

This study evaluated the effect of preoperative brimonidine tartrate 0.2% on intraocular pressure (IOP) during robotic-assisted laparoscopic radical prostatectomy (RALP) in steep Trendelenburg position (sTBURG).

Methods:

In this prospective randomized controlled masked interventional trial, eligible patients scheduled for RALP in sTBURG at the Toronto General Hospital had one eye randomized to placebo (artificial tears) or drug (brimonidine tartrate 0.2%) preoperatively. Visual acuity (VA), tonometry, disc photography, visual field (VF) and retinal nerve fiber layer (RNFL) assessments were performed pre- and postoperatively. A standardized anesthetic protocol was followed intraoperatively. IOP was measured using Tono-Pen AVIA (Reichert Inc., New York, USA) as follows: pre-anesthesia supine, anesthetized supine, hourly in sTBURG and awake supine. The primary outcome was IOP in sTBURG in the drug group compared to the placebo group. Secondary outcomes were changes in VA, VF, RNFL thickness, mean arterial pressure and ocular perfusion pressure. This study was approved by University Health Network Research Ethics Board.

Results:

Twenty-six eligible patients, mean age 61.9±5.1 years, were randomized to brimonidine (11) and placebo (15). Baseline IOP was not significantly different between the drug and placebo groups (P=0.42). Significant and sustained IOP elevation of >1.5X baseline in the sTBURG was noted in both groups. The mean IOP one hour after sTBURG was 29.4±6.9 and 27.2±3.4▒mmHg in the drug and placebo groups, respectively (P=0.35). No significant changes were noted in VA, VF or RNFL.

Conclusions:

Significant and sustained IOP increases occur during sTBURG. Preoperative brimonidine does not prevent IOP spikes in sTBURG.

Related Topics

    loading  Loading Related Articles