End-of-life decision making precedes many deaths in intensive care units (ICUs). In China, there are no guidelines for end-of-life decision making, and information on the frequency of such decisions is scarce. This article aimed to understand the end-of-life decision-making experiences and the influencing factors of 15 medical and nursing staff members from the general ICU department of a grade 3 hospital of Luzhou, Sichuan. We used the phenomenological method of qualitative research to explore the factors influencing end-of-life decision making through the experiences of participants. Data collection continued until information saturation was achieved. The factors affecting the end-of-life decision-making experience of ICU medical and nursing staff members included a negative physician-patient relationship associated with mistrust and potential conflict, a lack of awareness of palliative care, restrictive health policies, and economic factors. The main factors affecting the end-of-life decision making of ICU medical and nursing staff members were the economic conditions of the patient and current health care legislation. An effective coping mechanism should be established based on medical, economic, legal, and educational fields to normalize end-of-life decision making on the basis of a standard procedure and laws to effectively protect the interests of medical and nursing staff members as well as patients and their families.