Influence of drugs on blood pressure variability

    loading  Checking for direct PDF access through Ovid

Abstract

Aim

To study the causes of blood pressure variability by using antihypertensive drugs

Methods

Survey of published studies.

Results

The results are sometimes unclear and, for some drugs, contradictory. β-Adrenoceptor antagonists appear to have no effect on blood pressure variability, whereas α-adrenoceptor antagonists and atropine can lessen the amplitude of the variations. Similarly, there is a decrease after the administration of clonidine. Guanfacine, however, which acts on the same central receptors, does not lessen variability. Calcium antagonists do not influence blood pressure variability and the results with angiotensin converting enzyme inhibitors are contradictory

Conclusions

From these results we conclude that blood pressure variability is not dependent on β-receptor activity or calcium-mediated mechanisms. It is most likely that both α-adrenergic tone and the vagal system have significant effects on blood pressure variability.

Related Topics

    loading  Loading Related Articles