Blood pressure reduction during treatment: day and night or daytime only?

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Prognostic effects of day-night blood pressure difference: In the vast majority of patients with hypertension, blood pressure during sleep is approximately 10–15% lower than during waking hours, but these levels are still higher than those in normotensive subjects. In some patients, the difference in blood pressure between daytime and night-time is smaller than in others, and these patients have been shown to have more severe cardiovascular complications.

Conclusions: Maintaining uniform blood pressure control over 24 h seems to be a desirable goal, which can be achieved with long-acting antihypertensive drugs administered once daily.

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