OS 11-03 Role of renal nervous activity in the development of renovascular hypertension in rats

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Clinical studies have indicated that renal denervation (RDN) suppresses sympathetic overactivity in hypertensive patients, suggesting that afferent renal nerve activity (ARNA) enhances sympathetic outflow via central nervous system. To investigate the possible role of ARNA in the pathophysiology of renovascular hypertension, we examined the effect of RDN on blood pressure and urinary norepinephrine in two-kidney, one-clip (2K1C) Goldblatt rats.

Design and Method:

Male Wister-Kyoto rats were divided 3 groups: sham, 2K1C and 2K1C with RDN. Under anesthesia, all rats were implanted a telemetry device for measurement of arterial pressure (BP).


BP was initially increased in a similar fashion between 2K1C and 2K1C with RDN. However, after 2 weeks later, blood pressure elevation was gradually attenuated by RDN. Heart rate was not changed among the groups throughout the experiment. Urinary norepinephrine excretion was significantly increased in 2K1C as compared with sham rats. On the other hand, RDN prevented the elevation of urinary norepinephrine excretion to sham group levels.


These results suggest the potential role of ARNA in the development phase of renovascular hypertension.

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