This study was designed to clarify the effects of lifestyle modification on the improvement in the systolic blood pressure (SBP) response to exercise in normotensive females.Design and Method:
The subjects included 78 normotensive females with (n = 25; age, 58.2 ± 10.3 years) and without (n = 53; age, 46.4 ± 12.6 years) an exaggerated SBP response to exercise who were not taking any medications. An exaggerated SBP response to exercise was defined according to the criteria of the Framingham Study (peak SBP: ≥190 mmHg). A lifestyle modification program consisting of aerobic exercise and diet counseling was conducted for 12 weeks in the community. The brachial-ankle pulse wave velocity (baPWV), plasma nitrate/nitrite (NOx), plasma thiobarbituric acid-reactive substances (TBARS), high-sensitivity C-reactive protein (hs-CRP), fibrinogen levels and the white blood cell (WBC) count were measured before and after 12-week intervention as arteriosclerotic markers.Results:
After 12-week intervention, the percent change in SBP elevation to exercise decreased in an exaggerated SBP response group (p < 0.05). Moreover, the percent change in SBP elevation to exercise showed a significantly greater in an exaggerated SBP response group than in the normal SBP response group (p < 0.05). The WBC count, plasma NOx and TBARS levels improved in an exaggerated SBP response group (p < 0.05, respectively). The maximal oxygen uptake, body mass index, high- and low-density lipoprotein cholesterol, hs-CRP, baPWV and ankle brachial index improved in both groups (p < 0.05, respectively). In an exaggerated SBP response group, the stepwise multiple regression analysis showed that the percent change in SBP elevation to exercise was independently associated with the percent changes in baPWV and plasma NOx level (r2 = 0.647, p < 0.0001).Conclusions:
These results suggest that a lifestyle modification is considered to be important to reduce an exaggerated SBP response to exercise through by improving the arterial stiffness and vascular endothelial function.