MPS 02-06 AUGMENTATION INDEX (AI) AND SMOKING HABITS FROM VIEWPOINT OF EPIDEMIOLOGY – THE TANUSHIMARU STUDY –

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Abstract

Objective:

We investigated the relationship between augmentation index (AI) and coronary risk factors in community-dwelling Japanese.

Design and Method:

This cross-sectional study included 1,925 subjects (764 males and 1,161 females) aged 40 to 95 years who underwent a health check-up in a Japanese cohort of the Seven Countries Study, in Tanushimaru, a typical farming town on Kyushu Island in 2009. The subjects’ medical history, alcohol intake, smoking habit and current medications for hypertension, dyslipidemia and diabetes were ascertained by questionnaire. Radial arterial pressure wave analysis was used to obtain AI.

Results:

Univariate linear regression analysis demonstrated that coronary risk factors such as age (p < 0.001), female gender (p < 0.001), body mass index (p < 0.001; inversely), systolic (p < 0.001) and diastolic (p < 0.001) blood pressures, total cholesterol (p < 0.05) and smoking status (p < 0.01) were significantly associated with AI. A multiple step-wise linear regression analysis showed that female gender (p < 0.001), systolic blood pressure (p < 0.001), age (p < 0.001), body mass index (p < 0.001; inversely) and smoking status (p < 0.001) were significantly and independently related to AI. Especially, a linear and significant trend (p = 0.008) of AI values (%) was demonstrated by ANCOVA adjusted for age, gender, systolic blood pressure and body mass index.

Conclusions:

The present study demonstrated that AI values were significantly associated with habitual smoking in a dose-dependent manner in a Japanese general population.

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