MPS 02-07 ADHERENCE TO SINGLE-PILL AND TWO-PILL ANGIOTENSIN II RECEPTOR BLOCKERS/STATIN REGIMENS AND THEIR EFFICACY IN LOWERING BLOOD PRESSURE AND LIPID TARGETS IN KOREAN PATIENTS

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Abstract

Objective:

We compared treatment adherence to single-pill ARB/statin vs. two-pill ARB + statin regimens in Korean patients. In addition, we also assessed whether the use of these two combination therapies affects lowering blood pressure (BP) and lipid levels (i.e., cholesterols and triglyceride).

Design and Method:

This study, as retrospective, non-interventional observational, and multicenter study, included a total of 58 doctors from 51 hospitals. The case report form (CRF) for patients who met the inclusion and exclusion criteria was collected from each site. A total of 1,457 CRFs (single-pill ARB/statin: 757, two-pill ARB + statin: 700) of hypertensive outpatients with concomitant dyslipidemia were included for the analysis. We measured adherence of the single-pill and the two-pills using medication possession ratio (MPR). Mean changes in BP and lipids during the study period (first-last visit) were compared between the two combination therapies.

Results:

There was no significant differences in participants characteristics, except for a family history of hypertension and the number of other prescription medications, between the single-pill ARB/statin and two-pill ARB + statin groups. With regard to medical adherence, the mean MPR (0.918 vs. 0.916) and the percentage of ’adherent’ (MPR ≥ 80%) (91.19% vs. 88.91%) of patients taking a single-pill ARB/statin regimen were slightly, but not significantly higher than those of patients taking a two-pill ARB + statin. In contrast, the mean reductions in SBP and lipid levels (except for HDL cholesterol) in the single-pill ARB/statin group were significantly greater than those in the two-pill ARB + statin group.

Conclusions:

We found that there were no significant differences in medication adherence between the two combination therapies, whereas patients taking the single-pill ARB/statin regimen showed significantly lower BP and lipid levels than those taking the two-pill ARB + statin regimen. The proper planning of future studies, such as randomized clinical trials, is necessary to compare adherence and therapeutic effect of single-pill and two-pill regimens.

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