MPS 03-05 PREVALENCE AND RISK FACTORS OF ABNORMAL LEFT VENTRICULAR GEOMETRICAL PATTERNS IN IRBESARTAN-TREATED HYPERTENSIVES

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Abstract

Objective:

To investigate the prevalence of LV geometric patterns in a large Chinese irbesartan-treated hypertensive population.

Design and Method:

A total of 10883 subjects (6623men and 4260 women) were screened and 1181 irbesartan-treated hypertensive patients (488 men and 693 women) were enrolled in the present study. The LV geometry was classified into four patterns: normal; abnormal, defined as concentric remodeling; and concentric and eccentric hypertrophy based on the values of left ventricular mass index (LVMI) and relative wall thickness (RWT).

Design and Method:

Logistic regression model was used to determine the odds ratio and 95% confidence intervals of the risk factors of left ventricular hypertrophy.

Results:

The prevalence of LVH was 17.1% in irbesartan-treated hypertensive patients, much higher in women than in men (p < 0.01). The prevalence of LV geometrical patterns was 38.9%, 11.0% and 6.1% for concentric remodeling, concentric and eccentric hypertrophy, respectively. After adjustment of confounders in a multivariate logistic regression analysis, the risk factors for LVH and abnormal LV geometry were female, BMI, Apo B, TCH, whtr, and MAU.

Conclusions:

The prevalence of LVH and abnormal LV geometric patterns was higher in men (20.7%) than in women (14.7%), but not increased with age. Thus, it is crucial to improve the awareness of hypertension and adhesion to antihypertensive medication, and to control the risk of CV complications in irbesartan-treated hypertensive patients.

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