[PS 01-01] The relationship between plasma endothelin-1 concentrations and ET-1 gene polymorphism in men with essential hypertension

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Abstract

Objective:

To improve application of endothelin-1 (ET-1) plasma concentrations as a marker of endothelial dysfunction in patients with essential hypertension who are carriers of different ET-1 gene variants.

Design and Method:

The main group involved 112 men with essential hypertension (EH) and left ventricular hypertrophy (LVH), whose average age was 49,67 ± 0,69 years old. 79 men (49,01 ± 0,73 years old) made the control group.

Results:

The Lys198Lys genotype and the Lys allele of the ET-1 gene dominate among the healthy men and the patients with EH and LVH. Because of the low frequency of carriers of the genotype Asn198Asn men with genotypes Lys198Asn and Asn198Asn were combined as carriers of the Asn allele. In patients with EH and LVH average concentration of plasma ET-1 was 12,95 ± 0,17 fmol/ml and was significantly higher than in the control group (1,79 ± 0,08 fmol/ml) (р < 0,0000001). The highest concentration of ET-1 was found in carriers of the Asn allele of the ET-1 gene (Table 1).

Conclusions:

In both in the control group and in the patients with EH and LVH dominate the Lys allele and the genotype Lys198Lys of the ET-1 gene and the highest concentration of ET-1 was found in carriers of the Asn allele. In patients with EH and LVH average concentration of plasma ET-1 was significantly higher than in the control group.

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