[PS 01-06] Low Dentin Matrix Protein 1 is Associated with Vascular Calcifications in Peritoneal Dialysis Patients

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Abstract

Objective:

Recent reports demonstrated that dentin matrix protein 1 (DMP1) acts as an inhibitor of vascular calcification and might be a potential biomarker for chronic kidney disease-mineral and bone disorder, however, the role of DMP1 has never been explored in dialysis patients. We investigated the association between DMP1 levels and vascular calcification in prevalent peritoneal dialysis patients.

Design and Method:

We recruited 223 prevalent peritoneal dialysis patients (mean age, 52.1 ± 11.8 years; 116 [52.0%] patients were male) and divided them into high and low DMP1 groups according to log transformed plasma DMP1 levels. Lateral lumbar spine radiographs were used for measurement of vascular calcification. A multiple logistic regression analysis was performed to elucidate whether DMP1 is independently associated with vascular calcification.

Results:

The mean age was 52.1 ± 11.8 years, and 116 (52.0%) patients were male. The median value of log DMP1 was 0.91 (0.32–2.81 ng/mL), and presence of vascular calcification was observed in 116 (52.0%) patients. Low DMP1 group showed significantly higher presence of vascular calcification compare with high DMP1 group (72 [64.3%] vs 44 [39.6%], P < 0.001), but did not showed differences in comparison with the calcification score (2 [0–10] vs 2 [0–8], P = 0.533). The multiple logistic regression analysis indicated that DMP1 levels were independently associated with the presence of vascular calcification after adjustment for multiple confounding factors (odds ratio, 0.766; 95% confidence interval, 0.634–0.924; P = 0.005).

Conclusions:

We showed that low DMP1 levels were significantly associated with presence of vascular calcification in prevalent peritoneal dialysis patients even after adjustment for already known traditional risk factors. DMP1 might be considered the novel factor that contributing the pathophysiology of cardiovascular disease in dialysis patients.

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