[PS 01-30] EVALUATION OF SERUM LIPID PROFILE AMONG HYPERTENSIVE AND TYPE 2 DIABETES MELLITUS PATIENTS IN SUDAN

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Abstract

Objective:

The aim of the current study is to assess the impact of hyperglycemia and elevated blood pressure on serum lipid profile in Sudanese patients. The results will influence the monitoring and management policies so as to avoid complications related to hypertension and diabetes mellitus.

Design and Method:

This is a cross sectional case control study conducted in Khartoum state, Sudan at 2015. A total of 228 participants we enrolled in this study. Out of them 68 were known hypertensive, 42 were known diabetics, 24 were both hypertensive and diabetic and 94 were sex and age matched controls. Fasting blood glucose was measured by calibrated glucometer. Parameters of lipid profile were determined by using clinical chemistry analyser (Echo, Italy) and commercial kits (Biosystem, Spain).

Results:

Mean triacylglycerol level among hypertensive and hypertensive patients combined with diabetes was significantly higher than that of controls (p < 0.023, p < 0.007) respectively. Hypertensive patients combined with diabetes also showed significantly higher triacylglycerols level than the diabetic group (p < 0.019). Apart from fasting blood glucose, No significant difference was observed between diabetics and controls in all study parameters.

Conclusions:

In contrast to the reported data, our results clearly demonstrate that lipid profile is not influenced by type 2 diabetes mellitus. However, hypertension increases the level of triacylglycerols significantly. This increase is even worse when hypertension is combined with diabetes. Interestingly, neither diabetes nor hypertension alters the levels of cholesterol, LDL-C and HDL-C. Further studies are therefore recommended, probably at DNA level, to reveal the causes of low cholesterol level among Sudanese hypertensive and diabetic patients compared to other populations.

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