PS 02-08 Elevated Arterial Stiffness is Associated with Early Bone Loss in Healthy Subjects

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Both arterial stiffness and osteoporosis are the major causes of cardiovascular morbidity and mortality as well as age-related public health issues. We investigated the relationship between brachial-ankle pulse wave velocity (baPWV) for arterial stiffness and bone mineral density (BMD) for osteoporosis in healthy subjects.

Design and Method:

Participants in this study included 1,727 subjects (mean age: 55 ± 10 years, M:F = 914:813) who underwent routine health check-up between March 2009 and August 2011. We estimated baPWV using an automated oscillometric analyzer and BMD using dual energy x-ray absorptiometry and analyzed the gender difference after categorizing the subjects into 3 groups (normal, osteopenia, and osteoporosis) according to the World Health Organization (WHO) diagnostic classification.


There was a significant inverse correlation and gender difference between total BMD measured in the femur and right baPWV in both male (r = −0.136, p = 0.001) and female (r = −0.234, p < 0.001), respectively. In subgroup analysis according to the WHO diagnostic classification, there was a significant gender difference of right baPWV in normal (M:F = 1437 ± 203: 1309 ± 182 cm/sec, p < 0.001) and osteopenia group (M:F = 1508 ± 296: 1428 ± 243 cm/sec, p = 0.002), respectively. However, there was no gender difference in the osteoporosis group (1550 ± 316: 1570 ± 327 cm/sec, p = 0.616). After adjusting for age and gender, right baPWV was independently associated with osteopenia (Mvs.F = odds ratio (OR):1.003, 95% confidence interval(CI) 1.002-1.004, p < 0.001 vs. OR:1.003, 95%CI 1.001-1.009, p = 0.029, respectively) and osteoporosis (Mvs.F = OR:1.002, 95%CI 1.001-1.003, p < 0.001 vs. OR:1.005, 95%CI 1.001-1.009, p = 0.010, respectively) in both male and female, respectively.


Arterial stiffness is elevated even in the osteopenia. Therefore more specific therapeutic strategies are important for pathophysioloic understanding of vascular damage during early bone loss period.

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