We investigated the association of arterial stiffness, assessed by pulse wave velocity (PWV) with the prevalence, extent, and severity of coronary atheroma burden using coronary computed tomography angiography (CCTA) in community-dwelling Korean adults without chest pain.Design and Method:
We analyzed 749 individuals without known or suspected coronary artery disease (CAD) undergoing CCTA. Participants were divided into two groups according to the mean value of PWV: 1455 cm/sec. Obstructive CAD, as measured by CCTA, was defined as maximum intra-luminal stenosis ≥ 50%. We compared the prevalence, extent, and severity of coronary atheroma burden, including coronary artery calcium score (CACS), atheroma burden obstructive score (ABOS), segment involvement score (SIS), and segment stenosis score (SSS) between groups. Multivariable logistic regression analysis was also performed to identify independent predictors of CAD.Results:
Individuals with higher PWV possessed higher obstructive CAD (p < 0.001). Higher PWV was associated with greater degrees of CACS, ABOS, SIS, and SSS on CT scans (p < 0.001 for all). Multivariable analyses adjusted for conventional cardiovascular risk factors, including age, sex, and diabetes mellitus revealed that higher PWV was an independent predictor of obstructive CAD (odds ratio 2.694, confidence intervals 1.382–5.252, p = 0.004).Conclusions:
Arterial stiffness assessed by PWV was associated with higher prevalence, extent, and severity of coronary atherosclerosis as well as increased risk of obstructive CAD in asymptomatics.