PS 02-12 Analysis of serum stromal interaction molecules 1 (STIM1) in hypertension combining acute coronary syndrome

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Abstract

Objective:

The aim of this study is to explore the change of serum stromal interaction molecules 1 (STIM1) in the people with hypertension combining acute coronary syndrome.

Design and Method:

The study group was composed of 30 patients with primary hypertension combining acute coronary syndrome (ACS, A group) and 30 patients with primary hypertension (B group). The control group (C group) was composed of 30 healthy individuals. The severity of coronary artery disease was determined by the Gensini score. STIM1 concentration was measured via Elisa. SPSS19.0 was used for statistical analysis.

Results:

The expression level of STIM1 in patients with primary hypertension(607.69 ± 108.89 and 410.26 ± 71.86), inclouding A group and B group, was significantly higher than that in control (339.53 ± 66.39)(P < 0.05). Pearson correlation analysis showed that the expression level of STIM1 was positively correlated with Gensini Score(R = 0.836, P < 0.05). While the level of STIM1 was negatively correlated with left ventricular ejection fraction(R = −0.333, P < 0.05) and NO(R = −0.768, P < 0.05). Univariate Logistic regression analysis showed that sex (OR = 0.010), smoking (OR = 3.656), WBC (OR = 1.236), ApoA1 (OR = 0.014), Scr (OR = 1.033), ALT (OR = 1.043), NO (OR = 0.965) and STIM1 (OR = 1.023) were risk factors for ACS(P < 0.05). In addition, multivariable Logistic regression analysis showed that smoking (OR = 6.656) and STIM1 (OR = 1.026) were associated with ACS (P < 0.05).

Conclusions:

The expression level of STIM1 in patients with primary hypertension was higher than that in control. The expression level of STIM1 in patient with hypertension combining acute coronary syndrome (A group) was higher than in hypertension(B group). And the expression level of STIM1 was positively correlated with Gensini Score, which indicated that the expression level of STIM1 might reflect the severity of coronary artery lesions. The expression level of STIM1 was negatively correlated with NO. Which indicated that the expression level of STIM1 might reflect the endothelial function.

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