PS 02-18 MULTIPLE MEASUREMENTS OF HIGH-SENSITIVITY C-REACTIVE PROTEIN AND BRACHIAL-ANKLE PULSE WAVE VELOCITY IN NORTHERN CHINESE POPULATION

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Abstract

Objective:

CRP has proven to haave significant association with baPWV. However, few data exists regarding large population study in Chinese subjects. Our goal is to further make sure the link with CRP and baPWV in northern Chinese people, and compared multiple measurements of CRP and single measurements.

Design and Method:

101,510 employees and retirees received the health examinations between June 2006 and October 2007, and periodic examination were arranged every two years in the community of Kailuan Coal Group. Our data comes from the former three examinations. All the participants finished baPWV in 2010–2011 examination were enrolled into our study. After excluding the missing record of any time CRP or baPWV, and all the patients with diseases obviously affecting CRP were excluded. CumCRP was calculated as the CRP between two consecutive examinations multiplied by the time between the two examinations. 3 mg/L were regarded as the cut-off value of high CRP, and the exposure time of high CRP were grouped to analyze the different exposure time with artrial stiffness.

Results:

3,954 participants were enrolled into our final analysis. Partial correlations which adjusted for the age showed the positive relation between cumCRP and baPWV. Multivariate linear regression analysis further proved that with one standard deviation of cumulative CRP(SD = 7.2 mg/L·year) increasing, baPWV will increase 21.28 cm/s even adjusted for single CRP in baseline. Analysis of risk factors in baPWV≥1700 cm/s, which is a relatively cut-off for arterial stiffness showed that high CRP exposure time longer, the arterial stiffness developed more easily.

Conclusions:

Single measurement and multiple measurements were both associated with baPWV in northern Chinesepeople. Long-term high CRP exposure were risk factor of abnormal baPWV. And cumulative CRP calculated by multiple measurements, which more significantly associated with baPWV, could be a capable predictor or risk factor of arterial stiffness.

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