PS 02-19 APOLIPOPROTEIN LEVELS IN PATIENTS WITH ACUTE CORONARY SYNDROME: A PIONEER STUDY

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Abstract

Objective:

To determine the baseline apolipoprotein level among patients with Acute Coronary Syndrome.

Design and Method:

This is a Cross-sectional study involving 58 patients admitted at the Philippine General Hospital with Acute Coronary Syndrome (ACS) from October 2015 to January 2016. We measured concentrations of apolipoprotein B, apolipoprotein A-1, lipoprotein a, total cholesterol, triglyceride, LDL, HDL and calculated TC/HDL, TG/HDL and apoB:apoA-1 ratio within 24 hours upon admission.

Results:

48% percent was diagnosed with NSTE-ACS, 32.8% had STEMI and 19% had Unstable Angina. The mean age was 60.28 +10.363 and majority were males (67.2%). Majority have high levels of apolipoprotein B (> 90 mg/dl) at 63.8% followed by elevated levels of non-HDL (> 130 mg/dl) in 56.9%, elevated LDL levels (> 100 mg/dl) in 41.4% and elevated levels of lipoprotein (a) (> 35 mg/dl) in 37.9%. Elevated levels of total cholesterol (> 200 mg/dL) and triglyceride (> 150 mg/dl) were found in only 20.7% and 29% respectively. Low levels of HDL (< 40 mg/dl) and apolipoprotein A-1 (< 120 mg/dl) were found in 73% and 63.8% respectively. There was no significant difference between all lipid profile parameters and ACS classification. The apolipoprotein A-1 levels were significantly low in alcoholic patients and apolipoprotein B: apolipoprotein A-1 ratio were significantly elevated in diabetics.

Conclusions:

Elevated levels of apolipoprotein B, LDL, non-HDL and apoB:apoA1 ratio and low levels of apolipoprotein A-1 were highly prevalent in patients with ACS. Apolipoprotein B:Apolipoprotein A-1 ratio might be of greater value in assessing cardiovascular risk and treatment of patients especially in the diabetic population.

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